Angiotensin II induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling
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چکیده
منابع مشابه
Oxidative-stress-induced afterdepolarizations and calmodulin kinase II signaling.
In the heart, oxidative stress caused by exogenous H(2)O(2) has been shown to induce early afterdepolarizations (EADs) and triggered activity by impairing Na current (I(Na)) inactivation. Because H(2)O(2) activates Ca(2+)/calmodulin kinase (CaMK)II, which also impairs I(Na) inactivation and promotes EADs, we hypothesized that CaMKII activation may be an important factor in EADs caused by oxidat...
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Recent studies suggest a crucial role of reactive oxygen species (ROS) for the signaling of angiotensin (Ang) II through Ang II type 1 receptor (AT(1)-R). However, the role of ROS in the regulation of AT(1)-R expression has not been explored. In this study, we examined the effect of an antioxidant on the homologous downregulation of AT(1)-R by Ang II. Ang II (10(-6) mol/L) decreased AT(1)-R mRN...
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Peptide hormone Angiotensin II (Ang II) activates NAD(P)H oxidase, via AT1 receptors leading to increased generation of reactive oxygen species (ROS), such as the superoxide anion (O(2)(-)). As an important intracellular second messenger, ROS can activate many downstream signaling molecules, including mitogen-activated protein kinases (MAPK), protein tyrosine phosphatases, protein tyrosine kina...
متن کاملCellular Biology Oxidative Stress–Induced Afterdepolarizations and Calmodulin Kinase II Signaling
In the heart, oxidative stress caused by exogenous H2O2 has been shown to induce early afterdepolarizations (EADs) and triggered activity by impairing Na current (INa) inactivation. Because H2O2 activates Ca 2 /calmodulin kinase (CaMK)II, which also impairs INa inactivation and promotes EADs, we hypothesized that CaMKII activation may be an important factor in EADs caused by oxidative stress. U...
متن کاملAngiotensin II, reactive oxygen species, and Ca signaling in afferent arterioles
Fellner, Susan K., and William J. Arendshorst. Angiotensin II, reactive oxygen species, and Ca signaling in afferent arterioles. Am J Physiol Renal Physiol 289: F1012–F1019, 2005. First published June 7, 2005; doi:10.1152/ajprenal.00144.2005.—In afferent arteriolar vascular smooth muscle cells, ANG II induces a rise in cytosolic Ca ([Ca ]i) via inositol trisphosphate receptor (IP3R) stimulation...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2011
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2010.11.001